[HTML][HTML] Characterization of structural domains of human osteoclastogenesis inhibitory factor
K Yamaguchi, M Kinosaki, M Goto, F Kobayashi… - Journal of Biological …, 1998 - ASBMB
Osteoclastogenesis inhibitory factor (OCIF) is a heparin-binding secretory glycoprotein that
belongs to the tumor necrosis factor receptor (TNFR) family. OCIF is present both as a∼ 60-
kDa monomer and a disulfide-linked homodimer. We attempted to characterize the seven
structural domains of OCIF by determining the capabilities of various OCIF mutants to inhibit
osteoclastogenesis, to interact with heparin, and to form dimers. We also examined a
potential of domains 5 and 6, death domain homologous regions (DDHs), for inducing cell …
belongs to the tumor necrosis factor receptor (TNFR) family. OCIF is present both as a∼ 60-
kDa monomer and a disulfide-linked homodimer. We attempted to characterize the seven
structural domains of OCIF by determining the capabilities of various OCIF mutants to inhibit
osteoclastogenesis, to interact with heparin, and to form dimers. We also examined a
potential of domains 5 and 6, death domain homologous regions (DDHs), for inducing cell …