Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction
S Kanno, DL Lerner, RB Schuessler… - Journal of the american …, 2002 - Elsevier
Gene-targeting in mice is a powerful tool to define molecular mechanisms of ischemic heart
disease that determine infarct size, postinfarct left ventricular (LV) remodeling, and
arrhythmogenesis. Coronary ligation in mice is becoming a widely used model of myocardial
infarction (MI), but the pathophysiologic consequences of MI in mice and its relevance to
human MI have not been fully elucidated. To characterize structural and functional changes
during evolving MI, we analyzed 2-dimensional-based reconstruction of the left ventricle by …
disease that determine infarct size, postinfarct left ventricular (LV) remodeling, and
arrhythmogenesis. Coronary ligation in mice is becoming a widely used model of myocardial
infarction (MI), but the pathophysiologic consequences of MI in mice and its relevance to
human MI have not been fully elucidated. To characterize structural and functional changes
during evolving MI, we analyzed 2-dimensional-based reconstruction of the left ventricle by …