γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
WM Bonner, CE Redon, JS Dickey, AJ Nakamura, OA Sedelnikova, S Solier, Y Pommier
Nature Reviews Cancer, 2008•nature.comHistone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may
lead to cancer but, paradoxically, are also used to kill cancer cells. Using γH2AX detection to
determine the extent of DSB induction may help to detect precancerous cells, to stage
cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer
drugs.
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may
lead to cancer but, paradoxically, are also used to kill cancer cells. Using γH2AX detection to
determine the extent of DSB induction may help to detect precancerous cells, to stage
cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer
drugs.
Abstract
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using γH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
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