Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock
C Pangault, Y Le Tulzo, P Tattevin, V Guilloux… - Critical care …, 2006 - journals.lww.com
Objective: Loss of surface human leukocyte antigen-DR (HLA-DR) on monocytes is a major
factor of immunosuppression in sepsis. Granulocyte macrophage-colony stimulating factor
(GM-CSF) up-regulates HLA-DR expression on monocytes via the GM-CSF receptor (GM-
CSFr) through a transcriptional mechanism involving the class II transactivator factor (CIITA).
We investigated monocyte GM-CSFr expression and its relationship with HLA-DR in septic
patients. Design: Prospective clinical experimental study. Setting: University hospital …
factor of immunosuppression in sepsis. Granulocyte macrophage-colony stimulating factor
(GM-CSF) up-regulates HLA-DR expression on monocytes via the GM-CSF receptor (GM-
CSFr) through a transcriptional mechanism involving the class II transactivator factor (CIITA).
We investigated monocyte GM-CSFr expression and its relationship with HLA-DR in septic
patients. Design: Prospective clinical experimental study. Setting: University hospital …