[HTML][HTML] TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity
E Omori, S Morioka, K Matsumoto… - Journal of biological …, 2008 - ASBMB
Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to
hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the
mechanisms underlying this hypersensitivity. We found that TAK1 deficiency up-regulates
reactive oxygen species (ROS) resulting in cell death upon TNF or oxidative stress
challenge. Because blockade of NF-κB did not increase ROS or did not sensitize cells to
oxidative stress in keratinocytes TAK1 regulates ROS mainly through the mechanisms other …
hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the
mechanisms underlying this hypersensitivity. We found that TAK1 deficiency up-regulates
reactive oxygen species (ROS) resulting in cell death upon TNF or oxidative stress
challenge. Because blockade of NF-κB did not increase ROS or did not sensitize cells to
oxidative stress in keratinocytes TAK1 regulates ROS mainly through the mechanisms other …