[HTML][HTML] A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells
P López-Cotarelo, C Escribano-Díaz… - Journal of Biological …, 2015 - ASBMB
Chemokine receptor CCR7 directs mature dendritic cells (mDCs) to secondary lymph nodes
where these cells regulate the activation of T cells. CCR7 also promotes survival in mDCs,
which is believed to take place largely through Akt-dependent signaling mechanisms. We
have analyzed the involvement of the AMP-dependent kinase (AMPK) in the control of
CCR7-dependent survival. A pro-apoptotic role for AMPK is suggested by the finding that
pharmacological activators induce apoptosis, whereas knocking down of AMPK with siRNA …
where these cells regulate the activation of T cells. CCR7 also promotes survival in mDCs,
which is believed to take place largely through Akt-dependent signaling mechanisms. We
have analyzed the involvement of the AMP-dependent kinase (AMPK) in the control of
CCR7-dependent survival. A pro-apoptotic role for AMPK is suggested by the finding that
pharmacological activators induce apoptosis, whereas knocking down of AMPK with siRNA …