[HTML][HTML] Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis
PM Hansbro, MJ Hamilton, M Fricker, SL Gellatly… - Journal of Biological …, 2014 - ASBMB
Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell
(MC)-restricted protease of unknown function that is retained on the outer leaflet of the
plasma membrane when MCs are activated. We determined the nucleotide sequences of
the Prss31 gene in different mouse strains and then used a Cre/loxP homologous
recombination approach to create a novel Prss31−/− C57BL/6 mouse line. The resulting
animals exhibited no obvious developmental abnormality, contained normal numbers of …
(MC)-restricted protease of unknown function that is retained on the outer leaflet of the
plasma membrane when MCs are activated. We determined the nucleotide sequences of
the Prss31 gene in different mouse strains and then used a Cre/loxP homologous
recombination approach to create a novel Prss31−/− C57BL/6 mouse line. The resulting
animals exhibited no obvious developmental abnormality, contained normal numbers of …