Emerging concepts in T follicular helper cell responses to malaria
DS Hansen, N Obeng-Adjei, A Ly, LJ Ioannidis… - International journal for …, 2017 - Elsevier
Antibody responses to malaria and candidate malaria vaccines are short-lived in children,
leaving them susceptible to repeated malaria episodes. Because T follicular helper (T FH)
cells provide critical help to B cells to generate long-lived antibody responses, they have
become the focus of recent studies of Plasmodium-infected mice and humans. The
emerging data converge on common themes, namely, that malaria-induced T H1 cytokines
are associated with the activation of (i) T-like memory T FH cells with impaired B cell helper …
leaving them susceptible to repeated malaria episodes. Because T follicular helper (T FH)
cells provide critical help to B cells to generate long-lived antibody responses, they have
become the focus of recent studies of Plasmodium-infected mice and humans. The
emerging data converge on common themes, namely, that malaria-induced T H1 cytokines
are associated with the activation of (i) T-like memory T FH cells with impaired B cell helper …