The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells
E Ziesché, M Bachmann, H Kleinert… - Journal of Biological …, 2007 - jbc.org
Inducible nitric-oxide synthase (iNOS) has been identified as a marker and mediator of
disease in human colonic inflammation and carcinogenesis. Accordingly, identification of
mediators that trigger iNOS in colon carcinoma/epithelial cells is an important topic of current
research. Here we demonstrate that interleukin (IL)-22, a newly described member of the IL-
10 cytokine family, potently synergizes with interferon (IFN)-γ for iNOS expression in human
DLD-1 colon carcinoma cells. Detection of both IL-22 receptor chains and STAT3 …
disease in human colonic inflammation and carcinogenesis. Accordingly, identification of
mediators that trigger iNOS in colon carcinoma/epithelial cells is an important topic of current
research. Here we demonstrate that interleukin (IL)-22, a newly described member of the IL-
10 cytokine family, potently synergizes with interferon (IFN)-γ for iNOS expression in human
DLD-1 colon carcinoma cells. Detection of both IL-22 receptor chains and STAT3 …