IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
BACKGROUND: Psoriasis and atopic dermatitis (AD) are common inflammatory skin
diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although
potential involvement of TH17 T cells in AD was suggested during acute disease, the role of
these cells in chronic AD remains unclear. OBJECTIVE: To examine differences in IL-
23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets
in AD. METHODS: Skin biopsies and peripheral blood were collected from patients with …
diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although
potential involvement of TH17 T cells in AD was suggested during acute disease, the role of
these cells in chronic AD remains unclear. OBJECTIVE: To examine differences in IL-
23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets
in AD. METHODS: Skin biopsies and peripheral blood were collected from patients with …