[HTML][HTML] The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors
The recent recognition that antibody-mediated rejection (ABMR) is the major cause of kidney
transplant loss creates strong interest in its pathogenesis. We used microarray analysis of
kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR
transcript changes in the initial Discovery Set were strongly conserved in a subsequent
Validation Set. In the Combined Set of 703 biopsies, 2603 transcripts were significantly
changed (FDR< 0.05) in ABMR versus all other biopsies. In cultured cells, the transcripts …
transplant loss creates strong interest in its pathogenesis. We used microarray analysis of
kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR
transcript changes in the initial Discovery Set were strongly conserved in a subsequent
Validation Set. In the Combined Set of 703 biopsies, 2603 transcripts were significantly
changed (FDR< 0.05) in ABMR versus all other biopsies. In cultured cells, the transcripts …