[HTML][HTML] Increased metallothionein expression reflects steroid resistance in renal allograft recipients

NV Rekers, IM Bajema, MJK Mallat, JDH Anholts… - American Journal of …, 2013 - Elsevier
Steroid-refractory acute rejection is a risk factor for inferior renal allograft outcome. We
aimed to gain insight into the mechanisms underlying steroid resistance by identifying novel
molecular markers of steroid-refractory acute rejection. Eighty-three kidney transplant
recipients (1995–2005), who were treated with methylprednisolone during a first acute
rejection episode, were included in this study. Gene expression patterns were investigated
in a discovery cohort of 36 acute rejection biopsies, and verified in a validation cohort of 47 …