Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5
G Su, A Atakilit, JT Li, N Wu, J Luong, R Chen… - Critical care …, 2013 - journals.lww.com
Objective: Integrin αvβ5 has been identified as a regulator of vascular leak and endothelial
permeability. We hypothesized that targeting αvβ5 could represent a viable treatment
strategy for sepsis. Design: Integrin β5 subunit knockout and wild-type 129/svJae mice and
wild-type mice treated with αvβ5 blocking or control antibodies were tested in models of
intraperitoneal lipopolysaccharide and cecal ligation and puncture. Human umbilical vein
endothelial cell and human lung microvascular endothelial cell monolayers were treated …
permeability. We hypothesized that targeting αvβ5 could represent a viable treatment
strategy for sepsis. Design: Integrin β5 subunit knockout and wild-type 129/svJae mice and
wild-type mice treated with αvβ5 blocking or control antibodies were tested in models of
intraperitoneal lipopolysaccharide and cecal ligation and puncture. Human umbilical vein
endothelial cell and human lung microvascular endothelial cell monolayers were treated …