Role of innate immunity in primary graft dysfunction after lung transplantation
JM Diamond, CH Wigfield - Current opinion in organ …, 2013 - journals.lww.com
JM Diamond, CH Wigfield
Current opinion in organ transplantation, 2013•journals.lww.comInnate immune pathways are involved in the development of PGD and may provide
attractive targets for therapies. It may be possible to prevent or treat PGD, as well as to allow
pre-transplant PGD risk stratification. To improve understanding of the mechanisms behind
clinical risk factors for PGD will require further in-depth correlation of donor-specific and
recipient-related triggers of nonadaptive immune responses.
attractive targets for therapies. It may be possible to prevent or treat PGD, as well as to allow
pre-transplant PGD risk stratification. To improve understanding of the mechanisms behind
clinical risk factors for PGD will require further in-depth correlation of donor-specific and
recipient-related triggers of nonadaptive immune responses.
Summary
Innate immune pathways are involved in the development of PGD and may provide attractive targets for therapies. It may be possible to prevent or treat PGD, as well as to allow pre-transplant PGD risk stratification. To improve understanding of the mechanisms behind clinical risk factors for PGD will require further in-depth correlation of donor-specific and recipient-related triggers of nonadaptive immune responses.
Lippincott Williams & Wilkins