[HTML][HTML] JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
MTA Nguyen, H Satoh, S Favelyukis… - Journal of Biological …, 2005 - ASBMB
Lipid infusion and high fat feeding are established causes of systemic and adipose tissue
insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty
acids (FFAs) to investigate the molecular mechanisms underlying fat-induced insulin
resistance. FFA treatment impaired insulin receptor-mediated signal transduction and
decreased insulin-stimulated GLUT4 translocation and glucose transport. FFAs activated the
stress/inflammatory kinases c-Jun N-terminal kinase (JNK) and IKKβ, and the suppressor of …
insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty
acids (FFAs) to investigate the molecular mechanisms underlying fat-induced insulin
resistance. FFA treatment impaired insulin receptor-mediated signal transduction and
decreased insulin-stimulated GLUT4 translocation and glucose transport. FFAs activated the
stress/inflammatory kinases c-Jun N-terminal kinase (JNK) and IKKβ, and the suppressor of …