Marrow fat and bone—new perspectives
PK Fazeli, MC Horowitz, OA MacDougald… - The Journal of …, 2013 - academic.oup.com
The Journal of Clinical Endocrinology & Metabolism, 2013•academic.oup.com
Context: There is growing interest in the relationship between bone mineral density, bone
strength, and fat depots. Marrow adipose tissue, a well-established component of the
marrow environment, is metabolically distinct from peripheral fat depots, but its functional
significance is unknown. Objective: In this review, we discuss animal and human data
linking the marrow adipose tissue depot to parameters of bone density and integrity as well
as the potential significance of marrow adipose tissue in metabolic diseases associated with …
strength, and fat depots. Marrow adipose tissue, a well-established component of the
marrow environment, is metabolically distinct from peripheral fat depots, but its functional
significance is unknown. Objective: In this review, we discuss animal and human data
linking the marrow adipose tissue depot to parameters of bone density and integrity as well
as the potential significance of marrow adipose tissue in metabolic diseases associated with …
Context
There is growing interest in the relationship between bone mineral density, bone strength, and fat depots. Marrow adipose tissue, a well-established component of the marrow environment, is metabolically distinct from peripheral fat depots, but its functional significance is unknown.
Objective
In this review, we discuss animal and human data linking the marrow adipose tissue depot to parameters of bone density and integrity as well as the potential significance of marrow adipose tissue in metabolic diseases associated with bone loss, including type 1 diabetes mellitus and anorexia nervosa. Potential hormonal determinants of marrow adipose tissue are also discussed.
Conclusions
We conclude that whereas most animal and human data demonstrate an inverse association between marrow adipose tissue and measures of bone density and strength, understanding the functional significance of marrow adipose tissue and its hormonal determinants will be critical to better understanding its role in skeletal integrity and the role of marrow adipose tissue in the pathophysiology of bone loss.
Oxford University Press