[HTML][HTML] Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-α secretion through IKK regulation of …
Reactive oxygen species (ROS) are important second messengers generated in response to
many types of environmental stress. In this setting, changes in intracellular ROS can activate
signal transduction pathways that influence how cells react to their environment. In sepsis, a
dynamic proinflammatory cellular response to bacterial toxins (eg lipopolysaccharide or
LPS) leads to widespread organ damage and death. The present study demonstrates for the
first time that the activation of Rac1 (a GTP-binding protein), and the subsequent production …
many types of environmental stress. In this setting, changes in intracellular ROS can activate
signal transduction pathways that influence how cells react to their environment. In sepsis, a
dynamic proinflammatory cellular response to bacterial toxins (eg lipopolysaccharide or
LPS) leads to widespread organ damage and death. The present study demonstrates for the
first time that the activation of Rac1 (a GTP-binding protein), and the subsequent production …