Inflammation plays an important role in ischemic pathology. NF-κB is a transcription factor
that has a crucial role in inflammation and cell survival, but its precise role in the ischemic
aftermath is still uncertain. Therefore, we evaluated the effect of intracerebroventricular
administration of a highly specific NF-κB inhibitor peptide, IKK-NBD, on transient focal
cerebral ischemic injury in rat using middle cerebral artery occlusion model. The
assessment of ischemia-induced neurological deficits, alterations in the proinflammatory …