Cell biology of ischemia/reperfusion injury
T Kalogeris, CP Baines, M Krenz, RJ Korthuis - International review of cell …, 2012 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of
debilitating disease and death. Tissue injury and/or death occur as a result of the initial
ischemic insult, which is determined primarily by the magnitude and duration of the
interruption in the blood supply, and then subsequent damage induced by reperfusion.
During prolonged ischemia, ATP levels and intracellular pH decrease as a result of …
and peripheral vascular disease, continue to be among the most frequent causes of
debilitating disease and death. Tissue injury and/or death occur as a result of the initial
ischemic insult, which is determined primarily by the magnitude and duration of the
interruption in the blood supply, and then subsequent damage induced by reperfusion.
During prolonged ischemia, ATP levels and intracellular pH decrease as a result of …