Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine …
JJ Haddad, SC Land, WO Tarnow-Mordi… - The Journal of …, 2002 - Elsevier
In an attempt to elaborate in vitro on a therapeutic strategy that counteracts an inflammatory
signal, we previously reported a novel immunopharmacological potential of glutathione, an
antioxidant thiol, in regulating inflammatory cytokines. In the present study, we investigated
the hypothesis that selective regulation of phosphodiesterases (PDEs), a family of enzymes
that controls intracellular cAMP/cGMP degradation, differentially regulates proinflammatory
cytokines. Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) …
signal, we previously reported a novel immunopharmacological potential of glutathione, an
antioxidant thiol, in regulating inflammatory cytokines. In the present study, we investigated
the hypothesis that selective regulation of phosphodiesterases (PDEs), a family of enzymes
that controls intracellular cAMP/cGMP degradation, differentially regulates proinflammatory
cytokines. Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) …
