The Pharmacology of Two Novel Long-Acting Phosphodiesterase 3/4 Inhibitors, RPL554 [9, 10-Dimethoxy-2 (2, 4, 6-trimethylphenylimino)-3-(N-carbamoyl-2 …
V Boswell-Smith, D Spina, AW Oxford… - The Journal of …, 2006 - Elsevier
The pharmacology of two novel, trequinsin-like PDE3/4 inhibitors, RPL554 [9, 10-dimethoxy-
2 (2, 4, 6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3, 4, 6, 7-tetrahydro-2 H-
pyrimido-[6, 1-a] isoquinolin-4-one] and RPL565 [6, 7-dihydro-2-(2, 6-diisopropylphenoxy)-
9, 10-dimethoxy-4 H-pyrimido [6, 1-a] isoquinolin-4-one], has been investigated in a number
of in vitro and in vivo assays. Electrical field stimulation-induced contraction of guinea pig
superfused isolated tracheal preparations was significantly inhibited by RPL554 (10 μM) …
2 (2, 4, 6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3, 4, 6, 7-tetrahydro-2 H-
pyrimido-[6, 1-a] isoquinolin-4-one] and RPL565 [6, 7-dihydro-2-(2, 6-diisopropylphenoxy)-
9, 10-dimethoxy-4 H-pyrimido [6, 1-a] isoquinolin-4-one], has been investigated in a number
of in vitro and in vivo assays. Electrical field stimulation-induced contraction of guinea pig
superfused isolated tracheal preparations was significantly inhibited by RPL554 (10 μM) …
