Phosphodiesterase inhibitor modulation of brain microvascular endothelial cell barrier properties
S Liu, C Yu, F Yang, A Paganini-Hill… - Journal of the neurological …, 2012 - Elsevier
BACKGROUND AND PURPOSE: Brain microvascular disorders, including cerebral
microscopic hemorrhage, have high prevalence but few treatment options. To develop new
strategies for these disorders, we analyzed the effects of several phosphodiesterase (PDE)
inhibitors on human brain microvascular endothelial cells (HBECs). METHODS: We
modified barrier properties and response to histamine of HBECs using cilostazol (PDE3
inhibitor), rolipram (PDE4 inhibitor), and dipyridamole (non-specific PDE inhibitor) …
microscopic hemorrhage, have high prevalence but few treatment options. To develop new
strategies for these disorders, we analyzed the effects of several phosphodiesterase (PDE)
inhibitors on human brain microvascular endothelial cells (HBECs). METHODS: We
modified barrier properties and response to histamine of HBECs using cilostazol (PDE3
inhibitor), rolipram (PDE4 inhibitor), and dipyridamole (non-specific PDE inhibitor) …
