[HTML][HTML] Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis
B Steelant, SF Seys, L Van Gerven… - Journal of Allergy and …, 2018 - Elsevier
Background Allergic rhinitis (AR) is characterized by mucosal inflammation, driven by
activated immune cells. Mast cells and TH 2 cells might decrease epithelial barrier integrity
in AR, maintaining a leaky epithelial barrier. Objective We sought to investigate the role of
histamine and TH 2 cells in driving epithelial barrier dysfunction in AR. Methods Air-liquid
interface cultures of primary nasal epithelial cells were used to measure transepithelial
electrical resistance, paracellular flux of fluorescein isothiocyanate-dextran 4 kDa, and …
activated immune cells. Mast cells and TH 2 cells might decrease epithelial barrier integrity
in AR, maintaining a leaky epithelial barrier. Objective We sought to investigate the role of
histamine and TH 2 cells in driving epithelial barrier dysfunction in AR. Methods Air-liquid
interface cultures of primary nasal epithelial cells were used to measure transepithelial
electrical resistance, paracellular flux of fluorescein isothiocyanate-dextran 4 kDa, and …
