Anti-inflammatory profile of levosimendan in cecal ligation-induced septic mice and in lipopolysaccharide-stimulated macrophages
Q Wang, H Yokoo, M Takashina, K Sakata… - Critical Care …, 2015 - journals.lww.com
Objectives: The calcium sensitizer levosimendan is used in treatment of decompensated
heart failure and may also exhibit anti-inflammatory properties. We examined whether
treatment with levosimendan is substantially beneficial in mice with cecal ligation and
puncture–induced polymicrobial sepsis, and its arbitration mechanism was explored in the
mouse macrophage cell line RAW264. 7. Design: Laboratory and animal/cell research.
Setting: University research laboratory. Subjects: BALB/c mice (8–10 wk old) and mouse …
heart failure and may also exhibit anti-inflammatory properties. We examined whether
treatment with levosimendan is substantially beneficial in mice with cecal ligation and
puncture–induced polymicrobial sepsis, and its arbitration mechanism was explored in the
mouse macrophage cell line RAW264. 7. Design: Laboratory and animal/cell research.
Setting: University research laboratory. Subjects: BALB/c mice (8–10 wk old) and mouse …