Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury
D Mokra, A Drgova, R Pullmann Sr… - Pulmonary Pharmacology …, 2012 - Elsevier
Since inflammation and oxidation play a key role in the pathophysiology of neonatal
meconium aspiration syndrome, various anti-inflammatory drugs have been tested in the
treatment. This study evaluated whether the phosphodiesterase (PDE) 3 inhibitor olprinone
can alleviate meconium-induced inflammation and oxidative lung injury. Oxygen-ventilated
rabbits intratracheally received 4 ml/kg of meconium (25 mg/ml) or saline. Thirty minutes
after meconium/saline instillation, meconium-instilled animals were treated by intravenous …
meconium aspiration syndrome, various anti-inflammatory drugs have been tested in the
treatment. This study evaluated whether the phosphodiesterase (PDE) 3 inhibitor olprinone
can alleviate meconium-induced inflammation and oxidative lung injury. Oxygen-ventilated
rabbits intratracheally received 4 ml/kg of meconium (25 mg/ml) or saline. Thirty minutes
after meconium/saline instillation, meconium-instilled animals were treated by intravenous …