Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
JE Souness, D Aldous, C Sargent - Immunopharmacology, 2000 - Elsevier
It has been approximately a decade since early Ž studies Crummey et al., 1987; Torphy and
Undem,. 1991 first highlighted the anti-inflammatory and smooth muscle relaxant effects of
cyclic AMP phos-Ž. phodiesterase PDE 4 inhibitors that suggested their potential in the
treatment of asthma. During the intervening period, many pharmaceutical companies have
embarked on programs of work to identify their own PDE4 inhibitors, not only for the
treatment of asthma, but also other chronic inflammatory diseases such as arthritis, chronic …
Undem,. 1991 first highlighted the anti-inflammatory and smooth muscle relaxant effects of
cyclic AMP phos-Ž. phodiesterase PDE 4 inhibitors that suggested their potential in the
treatment of asthma. During the intervening period, many pharmaceutical companies have
embarked on programs of work to identify their own PDE4 inhibitors, not only for the
treatment of asthma, but also other chronic inflammatory diseases such as arthritis, chronic …