Inhibitory effect of milrinone on cytokine production after cardiopulmonary bypass
N Hayashida, H Tomoeda, T Oda, E Tayama… - The Annals of thoracic …, 1999 - Elsevier
N Hayashida, H Tomoeda, T Oda, E Tayama, S Chihara, T Kawara, S Aoyagi
The Annals of thoracic surgery, 1999•ElsevierBackground. It has been suggested that cyclic adenosine monophosphate-elevating agents
suppress cytokine production. To evaluate the effects of milrinone, a phosphodiesterase III
inhibitor, on cytokine production after cardiopulmonary bypass, we conducted a prospective
randomized study. Methods. Twenty-four patients undergoing coronary artery bypass
grafting were randomized to receive either milrinone treatment (milrinone, n= 12) or no
milrinone treatment (control, n= 12). Administration of milrinone (0.5 μg· kg− 1· min− 1) was …
suppress cytokine production. To evaluate the effects of milrinone, a phosphodiesterase III
inhibitor, on cytokine production after cardiopulmonary bypass, we conducted a prospective
randomized study. Methods. Twenty-four patients undergoing coronary artery bypass
grafting were randomized to receive either milrinone treatment (milrinone, n= 12) or no
milrinone treatment (control, n= 12). Administration of milrinone (0.5 μg· kg− 1· min− 1) was …
Background
It has been suggested that cyclic adenosine monophosphate-elevating agents suppress cytokine production. To evaluate the effects of milrinone, a phosphodiesterase III inhibitor, on cytokine production after cardiopulmonary bypass, we conducted a prospective randomized study.
Methods
Twenty-four patients undergoing coronary artery bypass grafting were randomized to receive either milrinone treatment (milrinone, n = 12) or no milrinone treatment (control, n = 12). Administration of milrinone (0.5 μg · kg−1 · min−1) was started after induction of anesthesia and was continued for 24 hours. Blood samples for determination of plasma cyclic adenosine monophosphate, tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-8 levels were collected perioperatively.
Results
No significant differences were observed in tumor necrosis factor-α and interleukin-8 levels between the groups. Interleukin-1β and interleukin-6 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the milrinone group than in the control group. Plasma levels of cyclic adenosine monophosphate increased significantly (p < 0.05) after the administration of milrinone and the levels correlated inversely (r = −0.55, p < 0.01) with interleukin-6 levels.
Conclusions
The results indicate that milrinone suppresses cytokine production by elevating cyclic adenosine monophosphate levels in patients undergoing cardiopulmonary bypass. With its positive inotropic and vasodilator activities, milrinone may have antiinflammatory effects.
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