Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats
RE Howell, LP Jenkins, LE Fielding, D Grimes - Pulmonary pharmacology, 1995 - Elsevier
Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to
inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting
that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used
extensively in preclinical drug development, a pulmonary antiinflammatory effect of PDE4
inhibition has not been demonstrated in this species. Therefore, we examined the effects of
rolipram, CI-930 (PDE3-selective inhibitor), zaprinast (PDE5-selective inhibitor) and …
inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting
that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used
extensively in preclinical drug development, a pulmonary antiinflammatory effect of PDE4
inhibition has not been demonstrated in this species. Therefore, we examined the effects of
rolipram, CI-930 (PDE3-selective inhibitor), zaprinast (PDE5-selective inhibitor) and …