The effect of selective phosphodiesterase inhibitors in comparison with other anti-asthma drugs on allergen-induced eosinophilia in guinea-pig airways
KH Banner, F Marchini, A Buschi, E Moriggi… - Pulmonary …, 1995 - Elsevier
The effects of isoenzyme selective phosphodiesterase (PDE) inhibitors and other anti-
asthma drugs on antigen-induced eosinophil recruitment and activation in guinea-pig
airways was studied. Guinea-pigs were sensitized and subsequently challenged with
aerosolized ovalbumin (OVA). Bronchoalveolar lavage (BAL) was performed 24 h later. A
significant increase in eosinophils and eosinophil peroxidase (EPO) was detected in BAL
fluid and BAL fluid supernatant respectively from OVA immunized guinea-pigs compared …
asthma drugs on antigen-induced eosinophil recruitment and activation in guinea-pig
airways was studied. Guinea-pigs were sensitized and subsequently challenged with
aerosolized ovalbumin (OVA). Bronchoalveolar lavage (BAL) was performed 24 h later. A
significant increase in eosinophils and eosinophil peroxidase (EPO) was detected in BAL
fluid and BAL fluid supernatant respectively from OVA immunized guinea-pigs compared …
