Are phosphodiesterase 4 inhibitors just more theophylline?
V Boswell-Smith, M Cazzola, CP Page - Journal of allergy and clinical …, 2006 - Elsevier
Theophylline has been relegated to a second-or even third-line therapy in the treatment of
asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids
and β2-agonists, although recent findings have suggested that theophylline possesses anti-
inflammatory and immunomodulatory effects in addition to its well-recognized effects as a
bronchodilator. In part, theophylline has fallen out of favor because of its adverse side-effect
profile, and this has led to the search for more effective and safer drugs based on the …
asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids
and β2-agonists, although recent findings have suggested that theophylline possesses anti-
inflammatory and immunomodulatory effects in addition to its well-recognized effects as a
bronchodilator. In part, theophylline has fallen out of favor because of its adverse side-effect
profile, and this has led to the search for more effective and safer drugs based on the …