Reduction in pulmonary hypertension and in airway resistances by enoximone (MDL 17,043) in decompensated COPD
M Leeman, P Lejeune, C Melot, R Naeije - Chest, 1987 - Elsevier
Hemodynamics, blood gas values, and lung mechanics were investigated in 19 patients with
decompensated COPD before and 30 and 60 minutes after a slow (15 minute) intravenous
administration of 3 mg/kg enoximone (MDL 17,043). In the first 11 patients who were
spontaneously breathing, enoximone significantly decreased pulmonary arterial wedge
pressure, right atrial pressure, mean systemic arterial pressure, and mean pulmonary
arterial pressure. Cardiac output remained unchanged, while heart rate increased slightly …
decompensated COPD before and 30 and 60 minutes after a slow (15 minute) intravenous
administration of 3 mg/kg enoximone (MDL 17,043). In the first 11 patients who were
spontaneously breathing, enoximone significantly decreased pulmonary arterial wedge
pressure, right atrial pressure, mean systemic arterial pressure, and mean pulmonary
arterial pressure. Cardiac output remained unchanged, while heart rate increased slightly …
