Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma
BACKGROUND: Cyclic AMP (cAMP) signaling modulates functions of inflammatory cells
involved in the pathogenesis of asthma, and type 4 cAMP-specific phosphodiesterases
(PDE4s) are essential components of this pathway. Induction of the PDE4 isoform PDE4B is
necessary for Toll-like receptor signaling in monocytes and macrophages and is associated
with T cell receptor/CD3 in T cells; however, its exact physiological function in the
development of allergic asthma remains undefined. OBJECTIVES: We investigated the role …
involved in the pathogenesis of asthma, and type 4 cAMP-specific phosphodiesterases
(PDE4s) are essential components of this pathway. Induction of the PDE4 isoform PDE4B is
necessary for Toll-like receptor signaling in monocytes and macrophages and is associated
with T cell receptor/CD3 in T cells; however, its exact physiological function in the
development of allergic asthma remains undefined. OBJECTIVES: We investigated the role …