Early steps in androgen biosynthesis: from cholesterol to DHEA
WL Miller - Baillière's clinical endocrinology and metabolism, 1998 - Elsevier
Sex steroids, both androgens and oestrogens, are made from dehydroepiandrosterone
(DHEA). The biosynthesis of DHEA from cholesterol entails four steps. First, cholesterol
enters the mitochondria with the assistance of a recently described factor called the
steroidogenic acute regulatory protein (StAR). Mutations in the StAR gene cause congenital
lipoid adrenal hyperplasia. Next, cholesterol is converted to pregnenolone by the cholesterol
side chain cleavage enzyme, P450scc. Mutations in the gene for P450scc and for its …
(DHEA). The biosynthesis of DHEA from cholesterol entails four steps. First, cholesterol
enters the mitochondria with the assistance of a recently described factor called the
steroidogenic acute regulatory protein (StAR). Mutations in the StAR gene cause congenital
lipoid adrenal hyperplasia. Next, cholesterol is converted to pregnenolone by the cholesterol
side chain cleavage enzyme, P450scc. Mutations in the gene for P450scc and for its …