Impact of hyperglycemia on the renin angiotensin system in early human type 1 diabetes mellitus
JA Miller - Journal of the American Society of Nephrology, 1999 - journals.lww.com
It has been demonstrated previously that moderate hyperglycemia without glucosuria can
increase plasma renin activity and mean arterial pressure in young healthy males with early
uncomplicated type 1 diabetes mellitus. This study was conducted to extend these
observations by testing the hypothesis that mild to moderate hyperglycemia can affect renal
function by increasing renin angiotensin system (RAS) activity in diabetic humans. The study
included 10 men and women with early, uncomplicated type 1 diabetes (duration< 5 yr), all …
increase plasma renin activity and mean arterial pressure in young healthy males with early
uncomplicated type 1 diabetes mellitus. This study was conducted to extend these
observations by testing the hypothesis that mild to moderate hyperglycemia can affect renal
function by increasing renin angiotensin system (RAS) activity in diabetic humans. The study
included 10 men and women with early, uncomplicated type 1 diabetes (duration< 5 yr), all …