Renin-angiotensin-aldosterone system blockade effects on the kidney in the elderly: benefits and limitations

F Turgut, RA Balogun… - Clinical Journal of the …, 2010 - journals.lww.com
The proportion of the population that is elderly (age≥ 65 years) is growing across the world.
The increasing longevity of humans results in a higher number of elderly patients' presenting
with multiple chronic diseases such as hypertension, diabetes, and chronic kidney disease
(CKD). These problems increase morbidity and mortality in the elderly. Overactivity of the
renin-angiotensin-aldosterone system (RAAS) is associated with the development of
hypertension, cardiovascular events, and CKD, so targeting the RAAS is a logical …