Mannose receptor-mediated regulation of serum glycoprotein homeostasis

SJ Lee, S Evers, D Roeder, AF Parlow, J Risteli… - Science, 2002 - science.org
SJ Lee, S Evers, D Roeder, AF Parlow, J Risteli, L Risteli, YC Lee, T Feizi, H Langen…
Science, 2002science.org
Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid
clearance. To examine the role of the mannose receptor (MR) in glycoprotein clearance, we
generated mice genetically deficient in MR. MR−/− mice were defective in clearing proteins
bearing accessible mannose and N-acetylglucosamine residues and had elevated levels of
eight different lysosomal hydrolases. Proteomic analysis of MR−/− and control mouse sera
showed that an additional 4 out of 52 proteins identified were elevated in MR−/− serum …
Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. To examine the role of the mannose receptor (MR) in glycoprotein clearance, we generated mice genetically deficient in MR. MR−/− mice were defective in clearing proteins bearing accessible mannose andN-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases. Proteomic analysis of MR−/− and control mouse sera showed that an additional 4 out of 52 proteins identified were elevated in MR−/−serum. Each of these is up-regulated during inflammation and wound healing. Thus, MR appears to operate as an essential regulator of serum glycoprotein homeostasis.
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