[PDF][PDF] Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association …
Journal of Clinical Oncology, 2014•slaop.org
Purpose Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-
hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum
2-HG would predict the presence of IDH1/2 mutations at diagnosis and provide a marker of
minimal residual disease (MRD).
hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum
2-HG would predict the presence of IDH1/2 mutations at diagnosis and provide a marker of
minimal residual disease (MRD).
Purpose
Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of IDH1/2 mutations at diagnosis and provide a marker of minimal residual disease (MRD).
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