Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial
M Rosenfeld, F Ratjen, L Brumback, S Daniel… - Jama, 2012 - jamanetwork.com
Context Inhaled hypertonic saline is recommended as therapy for patients 6 years or older
with cystic fibrosis (CF), but its efficacy has never been evaluated in patients younger than 6
years with CF. Objective To determine if hypertonic saline reduces the rate of protocol-
defined pulmonary exacerbations in patients younger than 6 years with CF. Design, Setting,
and Participants The Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS), a multicenter,
randomized, double-blind, placebo-controlled trial conducted from April 2009 to October …
with cystic fibrosis (CF), but its efficacy has never been evaluated in patients younger than 6
years with CF. Objective To determine if hypertonic saline reduces the rate of protocol-
defined pulmonary exacerbations in patients younger than 6 years with CF. Design, Setting,
and Participants The Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS), a multicenter,
randomized, double-blind, placebo-controlled trial conducted from April 2009 to October …