New animal models of cystic fibrosis: what are they teaching us?

NW Keiser, JF Engelhardt - Current opinion in pulmonary …, 2011 - journals.lww.com
Current opinion in pulmonary medicine, 2011journals.lww.com
Basic and clinical cystic fibrosis research will benefit greatly from the comparative
pathophysiology of cystic fibrosis mice, pigs, and ferrets. Both similarities and differences
between these three cystic fibrosis models will inform pathophysiologically important
mechanisms of CFTR function in humans and aid in the development of both organ-specific
and general therapies for cystic fibrosis.
Summary
Basic and clinical cystic fibrosis research will benefit greatly from the comparative pathophysiology of cystic fibrosis mice, pigs, and ferrets. Both similarities and differences between these three cystic fibrosis models will inform pathophysiologically important mechanisms of CFTR function in humans and aid in the development of both organ-specific and general therapies for cystic fibrosis.
Lippincott Williams & Wilkins