Organic carbamates in drug design and medicinal chemistry
AK Ghosh, M Brindisi - Journal of medicinal chemistry, 2015 - ACS Publications
Journal of medicinal chemistry, 2015•ACS Publications
The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are
specifically designed to make drug–target interactions through their carbamate moiety. In
this Perspective, we present properties and stabilities of carbamates, reagents and chemical
methodologies for the synthesis of carbamates, and recent applications of carbamates in
drug design and medicinal chemistry.
is an increasing use of carbamates in medicinal chemistry and many derivatives are
specifically designed to make drug–target interactions through their carbamate moiety. In
this Perspective, we present properties and stabilities of carbamates, reagents and chemical
methodologies for the synthesis of carbamates, and recent applications of carbamates in
drug design and medicinal chemistry.
The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.
ACS Publications