Imaging of apoptosis in the heart with nanoparticle technology
HH Chen, L Josephson… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
HH Chen, L Josephson, DE Sosnovik
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2011•Wiley Online LibraryApoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and
heart failure. Pioneering work with single photon emission computed tomography imaging of
99Tc‐annexin showed that cell death in the heart could be imaged in vivo. Over the last 5
years a significant amount of experience with annexin‐labeled magnetic nanoparticles,
principally AnxCLIO‐Cy5. 5, has also been gained. Here, we review the experience with
AnxCLIO‐Cy5. 5 in the heart and compare this experience to that of earlier studies with 99Tc …
heart failure. Pioneering work with single photon emission computed tomography imaging of
99Tc‐annexin showed that cell death in the heart could be imaged in vivo. Over the last 5
years a significant amount of experience with annexin‐labeled magnetic nanoparticles,
principally AnxCLIO‐Cy5. 5, has also been gained. Here, we review the experience with
AnxCLIO‐Cy5. 5 in the heart and compare this experience to that of earlier studies with 99Tc …
Abstract
Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of 99Tc‐annexin showed that cell death in the heart could be imaged in vivo. Over the last 5 years a significant amount of experience with annexin‐labeled magnetic nanoparticles, principally AnxCLIO‐Cy5.5, has also been gained. Here, we review the experience with AnxCLIO‐Cy5.5 in the heart and compare this experience to that of earlier studies with 99Tc‐annexin. The imaging of apoptosis with AnxCLIO‐Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general. WIREs Nanomed Nanobiotechnol 2011 3 86–99 DOI: 10.1002/wnan.115
This article is categorized under:
- Diagnostic Tools > In Vitro Nanoparticle-Based Sensing
- Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
- Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease
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