[HTML][HTML] The challenge of inhibiting alloreactive T-cell memory
A Valujskikh - American journal of transplantation, 2006 - Elsevier
Memory T cells specific for donor antigens present a unique challenge in transplantation. In
addition to expressing rapid and robust immune responses to a transplanted organ, memory
T cells may be resistant to the effects of currently used graft-prolonging therapies. The
increasing recognition that alloreactive memory T cells participate in transplant rejection is
driving new lines of research focusing on understanding the immunobiology of alloreactive
memory T cells and on designing novel therapies to specifically target memory T cells. The …
addition to expressing rapid and robust immune responses to a transplanted organ, memory
T cells may be resistant to the effects of currently used graft-prolonging therapies. The
increasing recognition that alloreactive memory T cells participate in transplant rejection is
driving new lines of research focusing on understanding the immunobiology of alloreactive
memory T cells and on designing novel therapies to specifically target memory T cells. The …
