[HTML][HTML] FR104, an antagonist anti-CD28 monovalent fab'antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal …
N Poirier, N Dilek, C Mary, S Ville, F Coulon… - American Journal of …, 2015 - Elsevier
Selective targeting of CD28 might represent an effective immunomodulation strategy by
preventing T cell costimulation, while favoring coinhibition since inhibitory signals
transmitted through CTLA-4; PD-L1 and B7 would not be affected. We previously showed in
vitro and in vivo that anti-CD28 antagonists suppress effector T cells while enhancing
regulatory T cell (Treg) suppression and immune tolerance. Here, we evaluate FR104, a
novel antagonist pegylated anti-CD28 Fab'antibody fragment, in nonhuman primate renal …
preventing T cell costimulation, while favoring coinhibition since inhibitory signals
transmitted through CTLA-4; PD-L1 and B7 would not be affected. We previously showed in
vitro and in vivo that anti-CD28 antagonists suppress effector T cells while enhancing
regulatory T cell (Treg) suppression and immune tolerance. Here, we evaluate FR104, a
novel antagonist pegylated anti-CD28 Fab'antibody fragment, in nonhuman primate renal …
