The effect of chronic kidney disease on T cell alloimmunity
PD Winterberg, ML Ford - Current opinion in organ transplantation, 2017 - journals.lww.com
PD Winterberg, ML Ford
Current opinion in organ transplantation, 2017•journals.lww.comThe mechanisms by which CKD alters the differentiation and activation status of T-cell
subsets is poorly understood. Further research is also needed to understand which cell
populations mediate rejection under various immunosuppressive regimens. To date, there is
little use of animal models of organ failure in transplant immunology research. CKD mouse
models may help identify novel pathways and targets to better control alloimmunity in
posttransplant.
subsets is poorly understood. Further research is also needed to understand which cell
populations mediate rejection under various immunosuppressive regimens. To date, there is
little use of animal models of organ failure in transplant immunology research. CKD mouse
models may help identify novel pathways and targets to better control alloimmunity in
posttransplant.
Summary
The mechanisms by which CKD alters the differentiation and activation status of T-cell subsets is poorly understood. Further research is also needed to understand which cell populations mediate rejection under various immunosuppressive regimens. To date, there is little use of animal models of organ failure in transplant immunology research. CKD mouse models may help identify novel pathways and targets to better control alloimmunity in posttransplant.
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