Microglia are the primary mediators of the immune defense system of the CNS and are
integral to the subsequent inflammatory response. The role of microglia in the injured CNS is
under scrutiny, as research has begun to fully explore how postinjury inflammation
contributes to secondary damage and recovery of function. Whether microglia are good or
bad is under debate, with strong support for a dual role or differential activation of microglia.
Microglia release a number of factors that modulate secondary injury and recovery after …