Pericytes from human non-small cell lung carcinomas: an attractive target for anti-angiogenic therapy

RG Bagley, C Rouleau, SD Morgenbesser… - Microvascular …, 2006 - Elsevier
Anti-angiogenic strategies have largely focused on endothelial cells and progenitors.
However, pericytes are also an important component of vasculature. Perivascular cells from
normal tissues have been widely reported, yet have not been extensively studied from
human tumors. We have investigated pericytes from tumors of patients with lung cancer, the
leader of cancer-related deaths in both men and women. Antibodies and magnetic beads
were used to isolate cells from non-small cell lung carcinomas (NSCLC). The morphology of …