[HTML][HTML] Two hepatic enhancers, HCR. 1 and HCR. 2, coordinate the liver expression of the entire human apolipoprotein E/CI/C-IV/C-II gene cluster
CM Allan, S Taylor, JM Taylor - Journal of Biological Chemistry, 1997 - ASBMB
We show that the liver-specific expression of all four genes in the human apolipoprotein
(apo) E/CI/C-IV/C-II gene cluster in transgenic mice is determined by the coordinate action of
two distinct hepatic control regions (HCR). These enhancers are positioned 15 kilobases
(kb)(HCR. 1) and 26 kb (HCR. 2) downstream of the apoE gene. To investigate the action of
each HCR, transgenic mice were generated with a 70-kb human genomic fragment that
contained the complete apoE gene cluster or with this fragment modified by the specific …
(apo) E/CI/C-IV/C-II gene cluster in transgenic mice is determined by the coordinate action of
two distinct hepatic control regions (HCR). These enhancers are positioned 15 kilobases
(kb)(HCR. 1) and 26 kb (HCR. 2) downstream of the apoE gene. To investigate the action of
each HCR, transgenic mice were generated with a 70-kb human genomic fragment that
contained the complete apoE gene cluster or with this fragment modified by the specific …