[HTML][HTML] VKORC1L1, an enzyme rescuing the vitamin K 2, 3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy
A Hammed, B Matagrin, G Spohn, C Prouillac… - Journal of Biological …, 2013 - ASBMB
Background: Effective involvement of VKORC1L1 in vitamin K epoxide reductase activity,
target of vitamin K antagonists (VKAs), is still unclear. Results: VKORC1L1 is not inhibited by
VKAs and catalyzes VKOR activity in extrahepatic tissues. Conclusion: During long term
anticoagulation the limited unwanted side effects of VKAs are due to VKORC1L1.
Significance: Potential pharmaco-toxicologic effects of specific VKORC1L1 inhibitors should
be assessed. Vitamin K is involved in the γ-carboxylation of the vitamin K-dependent …
target of vitamin K antagonists (VKAs), is still unclear. Results: VKORC1L1 is not inhibited by
VKAs and catalyzes VKOR activity in extrahepatic tissues. Conclusion: During long term
anticoagulation the limited unwanted side effects of VKAs are due to VKORC1L1.
Significance: Potential pharmaco-toxicologic effects of specific VKORC1L1 inhibitors should
be assessed. Vitamin K is involved in the γ-carboxylation of the vitamin K-dependent …