Vitamin K‐dependent carboxylation

KL Berkner - Vitamins & Hormones, 2008 - Elsevier
Vitamin K‐dependent (VKD) protein carboxylation uses vitamin K epoxidation to convert
Glus to carboxylated Glus (Glas), rendering VKD proteins active in physiologies that include
hemostasis, apoptosis, bone mineralization, calcium homeostasis, growth control, and
signal transduction. Clusters of Glus are modified by a processive carboxylase, generating a
calcium‐binding module that allows binding to either hydroxyapatite in the extracellular
matrices or cell surfaces where anionic phospholipids become exposed, for example, during …