β-Arrestins, originally discovered as terminators of G protein-coupled receptor signaling,
have more recently been appreciated to also function as signal transducers in their own
right, although the consequences for cellular physiology have not been well understood.
Here we demonstrate that β-arrestin-2 mediates anti-apoptotic cytoprotective signaling
stimulated by a typical 7-transmembrane receptor the angiotensin ATII 1A receptor,
expressed endogenously in rat vascular smooth muscle cells or by transfection in HEK-293 …